Police and emergency services were called to reports of a man and teenage girl caught in floodwaters near the Burnett Highway and Murgon Gayndah Roads at Booubyjan (near Gympie) in the early hours of Saturday.
It is believed the pair were in a Toyota Camry sedan and managed to get out of the vehicle before it was swept away.
Deluged roads and extreme weather conditions caused difficulty for crews and aerial assets.
Shortly before 12.30pm a 40-year-old man was rescued after being located clinging to a tree and taken to Bundaberg Hospital for treatment.
Searching continues for a 14-year-old girl still missing.
There is no further information available at this time.